Renee (Noomi Rapace) is a single mom who lives with her twelve-year-old son, Evan, in a quiet, suburban home. However, unbeknownst to them, their every move is being observed. While out running errands, Renee's car breaks down, and she is violently kidnapped by a group of strangers. She awakes in an anonymous laboratory, where she is tied up and questioned about her medical history, including her great fear of spiders. Renee soon discovers that she is now the subject of an underground experiment. Her captors explain to her that she has a genetic abnormality that can potentially allow her to "rupture," and reveal her alien nature.